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Ways of Enhancing Preclinical Imaging. Preclinical models and the accompanying modalities are special tools that are used in the study of particular aspects of disease such as neurodegeneration in the case of diseases of the nervous system, well, the following tips help to ensure imaging in a preclinical space generates comprehensible data across all disease states and thus assisting drug developers to better design and monitor clinical trials and bring drugs to the market faster. Prior to engaging in a study, connect preclinical imaging specialists if possible with specialists from elsewhere within the field (preclinical translation and clinical development) to evaluate the translatability of all the components of the model. The relevance of a certain particular disease model and the nature of the disease being studied must always be taken into account because without a clear model to serve as a reference, one will not be able to understand one aspect of the disease being studied.
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Once you factor in several things, then scaling from rodents to humans may not be as easy as it seems but there has to be a very straightforward translational aspects that rely on certain parameters.
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Modeling paradigms must be examined in junction with the timing and the results of the relevant studies that is related to the imaging endpoints. Whenever possible, it is critical that prior data is availed by the imaging group that shows either a discernible deficit within the modeling paradigm or that the parameters under study can actually be examined by the body conducting the study. Data from the specific scanners and the representative data and analysis by the team that collects the data using the scanners is critical, also, not that performing the same study with a different scanner can have an adverse change on the interpretation of the outcomes of the study. The particular animal model and the specific imaging techniques applied and the data analysis selected may all have an effect on the eventual results, this becomes of utmost importance when possibly subtle changes upon drug treatment are under scrutiny. Studying the possibilities and the limitations of the disease model comes next to proper imagery because this would help the study determine the scope of the study and when a subject should be replaced. These terms can be quite confusing, but they can work hand-in-hand in studies, however, it is important to use the opportunity provided by imaging time per subject to get all the right information and retain high throughput. Of course, do not forget to discuss with experts the methodologies possible for the study to retain the expectations for the study and make it easier to interpret the data coming from imaging studies.